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Progressive Supranuclear Palsy Treatment Research Pipeline

This tracker focuses on treatments being studied to change the underlying biology or course of progressive supranuclear palsy (PSP)—not medications being studied only to manage symptoms.

PSP involves abnormal buildup of tau protein in the brain. Select a treatment to see how it works, what the evidence shows so far, and where to find its registered clinical trial.

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Alzheimer's DiseaseLewy Body Dementia / Parkinson's Disease DementiaFrontotemporal DementiaVascular Cognitive Impairment / Vascular DementiaProgressive Supranuclear Palsy (PSP)Corticobasal Syndrome (CBS) / Corticobasal Degeneration (CBD)Multiple System Atrophy (MSA)

Treatment Pathways

Managing Symptoms Now

Treatments and strategies currently used to help with symptoms and day-to-day function.

Explore symptom management

Treatments Being Studied

Investigational approaches researchers are testing to slow, prevent, or change the underlying disease.

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Phase 1

Safety & dosing

Does it appear safe enough to keep studying?

The first studies in people. Researchers are primarily looking at safety, dosing, and how the treatment behaves in the body.

Phase 2

Early signals

Does it affect its target, and is there evidence it might help?

The treatment is tested in more people. Researchers continue studying safety while looking for evidence that it affects its intended target and may provide clinical benefit.

Phase 3

Large-scale testing

Does it meaningfully help patients, and is it sufficiently safe?

Large studies designed to determine whether the treatment is effective and sufficiently safe in the intended patient population. Positive Phase 3 results can support an application for regulatory approval.

A later phase does not mean a treatment is proven to work. Until a treatment has successfully completed clinical testing and received regulatory approval, it remains investigational.

Last pipeline review: September 15, 2026

This is a curated educational resource, not a comprehensive registry. Treatments are selected to illustrate clinically relevant approaches being studied for each disease. Trial status, enrollment, and eligibility should always be confirmed directly through ClinicalTrials.gov.

This pipeline is under active review. Treatment details and trial information are being expanded as individual programs are verified.